A naturally occurring compoundmade in the body, alpha lipoic acidserves an essential role in vitalfunctions at the cellular level,particularly in energy production.Research has shown this antioxidantis effective in moderating bloodsugar levels in humans, while alsoreducing metabolic hormoneresistance. In one study conducted in1997, alpha lipoic acid was found tohelp reduce blood glucose levels by up to 64%.

Mostly thought of as an aromaticspice in breakfast cereals and bakedgoods, cinnamon has a history of usein natural medicine for thousands ofyears. Researchers have found thatcinnamon can imitate the effects ofmetabolic hormones by promotingthe movement of glucose from bloodinto cells, thereby moderating bloodsugar levels. A 2015 clinical studyfound cinnamon increased metabolichormone sensitivity and glucoseutilization the most of all 49 naturalcompounds tested.

A naturally occurring alkaloid foundin many different types of plants andshrubs, berberine has a long historyof use in traditional Chinese medicinefor a variety of digestive ailments.Most importantly, a large body ofevidence has been established for itsability to enhance metabolic hormonesensitivity, help the body break downsugar, and help support healthyglucose production in the liver. In2008, a clinical study determinedthat daily berberine supplementationled to a 44.7% improvement inmetabolic hormone sensitivity.

One of the most commonly occurring
minerals in the earth's crust andseawater, chromium is an "essentialtrace element," a natural mineralcrucial to human health in small
doses. Science has firmly
established chromium's role inglucose metabolism, and researchhas confirmed the mineral can
improve metabolic hormonesensitivity and balance blood sugarlevels. In one clinical study publishedin 2004, twice daily chromiumsupplementation resulted in a 21%reduction in blood sugar levels.

Also known as bitter gourd or wildcucumber, bitter melon is a fruitwhich, as its name indicates, growsmore and more bitter as it ripens. Acommon culinary ingredient in EastAsian cuisines, bitter melon has alsobeen used extensively in traditionalmedicine for its ability to helpbalance blood sugar levels. A 2017study found that bitter melonenhanced metabolic hormonesensitivity, improving glucoseabsorption from the bloodstream.